Since you already have strong religious and expansion achievements (Defender of the Faith, True Catholic, and global conquest-style ones), aiming for owning multiple Reformation centers and then pushing profitable tropical trade by getting spice production and forming Malaya builds on your religious/expansion experience while remaining achievable and synergistic.

You’ve already completed many HRE- and Europe-focused achievements, so dismantling the HRE, becoming an elector as a non-elector, and forming Germany naturally build on your existing playstyle and regional knowledge and are achievable next steps that reinforce each other.